MicroRNA - 378 regulates oocyte maturation via the suppression of aromatase in porcine 1 cumulus cells
نویسندگان
چکیده
MicroRNA-378 regulates oocyte maturation via the suppression of aromatase in porcine 1 cumulus cells 2 Bo Pan, Derek Toms, Wei Shen, Julang Li 3 Department of Animal and Poultry Science, University of Guelph, Guelph, Ontario 4 Laboratory of Germ Cell Biology, College of Animal Science and Technology, Qingdao 5 Agricultural University, Qingdao, China 6 7 Abbreviated title: Cumulus cell miR-378 impairs oocyte maturation 8 Key terms: oocyte, cumulus, microRNA-378 9 Word count: 3000 10 Number of figures and tables: 9 11 12 Corresponding author and person to whom reprint requests should be addressed: 13 Julang Li, PhD 14 Department of Animal and Poultry Science 15 University of Guelph 16 50 Stone Road E, Guelph, ON N1G 2W1 17 Phone: +1-519-824-4120 18 Fax: +1-519-82419 Email: [email protected] 20 21 Disclosure statement: The authors have nothing to disclose. 22 23 Articles in PresS. Am J Physiol Endocrinol Metab (January 27, 2015). doi:10.1152/ajpendo.00480.2014
منابع مشابه
MicroRNA-378 regulates oocyte maturation via the suppression of aromatase in porcine cumulus cells.
We sought to investigate whether miR-378 plays a role in cumulus cells and whether the manipulation of miRNA levels in cumulus cells influences oocyte maturation in vitro. Cumulus-oocyte complexes (COCs) from ovarian follicles had significantly lower levels of precursor and mature miR-378 in cumulus cells surrounding metaphase II (MII) oocytes than cumulus cells surrounding germinal vesicle (GV...
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